期刊
CHROMATOGRAPHIA
卷 80, 期 5, 页码 783-791出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10337-017-3283-5
关键词
High-performance liquid chromatography; Magnetic solid-phase extraction; Ionic liquid dispersive liquid-liquid microextraction; Cosmetics; Hexachlorophene
资金
- Analysis and Testing Center of Kunming University of Science and Technology
An efficient, simple, and fast method based on ionic liquid dispersive liquid-liquid microextraction (IL-DLLME) followed by magnetic solid-phase extraction (MSPE) was developed as a new technique for extracting and purifying hexachlorophene (HCP) in cosmetics prior to high-performance liquid chromatography (HPLC) determination. In this method based on IL-DLLME and MSPE, 1-hexyl-3-methylimidazolium hexafluorophosphate ([C6MIM][PF6]) is used as the extraction solvent and Fe3O4 nanoparticles are used to remove hydrophobic additives in the cosmetics by physical adsorption. The main parameters affecting the efficiency of the IL-DLLME and MSPE of HCP were investigated and optimized. Under the optimum conditions, the method was linear in the range 0.5-40 A mu g mL(-1) with a correlation coefficient (R (2)) of 0.9976 and had a detection limit of 0.14 A mu g mL(-1) at a signal-to-noise ratio (S/N) of 3. The recoveries of HCP in three cosmetic samples using the proposed method were in the range 74.5-97.7%, and the relative standard deviations (RSD, n = 5) were in the range 3.8-6.7%. The developed method was successfully applied to the determination of HCP in cosmetics.
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