期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 42, 期 3, 页码 1933-1940出版社
WILEY
DOI: 10.1111/ejn.12953
关键词
sensorimotor cortex; tactile stimuli; tDCS
资金
- National Natural Science Foundation of China [11372013]
- Sidney Baer Foundation
- KL2 Medical Research Investigator Training (MeRIT) award from Harvard Catalyst/The Harvard Clinical and Translational Science Center [1KL2RR025757-04, UL 1RR025758]
- K01 award from the National Institute on Aging [1K01AG044543-01A1]
Tactile stimuli produce afferent signals that activate specific regions of the cerebral cortex. Noninvasive transcranial direct current stimulation (tDCS) effectively modulates cortical excitability. We therefore hypothesised that a single session of tDCS targeting the sensory cortices would alter the cortical response to tactile stimuli. This hypothesis was tested with a block-design functional magnetic resonance imaging protocol designed to quantify the blood oxygen level-dependent response to controlled sinusoidal pressure stimulation applied to the right foot sole, as compared with rest, in 16 healthy young adults. Following sham tDCS, right foot sole stimulation was associated with activation bilaterally within the precentral cortex, postcentral cortex, middle and superior frontal gyri, temporal lobe (subgyral) and cingulate gyrus. Activation was also observed in the left insula, middle temporal lobe, superior parietal lobule, supramarginal gyrus and thalamus, as well as the right inferior parietal lobule and claustrum (false discovery rate corrected, P<0.05). To explore the regional effects of tDCS, brain regions related to somatosensory processing, and cortical areas underneath each tDCS electrode, were chosen as regions of interest. Real tDCS, as compared with sham tDCS, increased the percent signal change associated with foot stimulation relative to rest in the left posterior paracentral lobule. These results indicate that tDCS acutely modulated the cortical responsiveness to controlled foot pressure stimuli in healthy adults. Further study is warranted, in both healthy individuals and patients with sensory impairments, to link tDCS-induced modulation of the cortical response to tactile stimuli with changes in somatosensory perception.
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