期刊
ADVANCED HEALTHCARE MATERIALS
卷 6, 期 18, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201700311
关键词
cardiac tissue engineering; cell orientation; functional scaffolds; melt electrospinning writing; polymer processing
资金
- strategic alliance University Medical Center Utrecht-Eindhoven University of Technology
- European Research Council (ERC) [647426, 617989]
- Dutch Heart Foundation
- Dutch Federation of University Medical Centers
- Netherlands Organization for Health Research and Development
- Royal Netherlands Academy of Science
- European Commission, Marie Curie Individual Fellowships Program [708459]
- Hofvijverkring Fellowship
- ReumaFonds [LLP-12] Funding Source: researchfish
- Marie Curie Actions (MSCA) [708459] Funding Source: Marie Curie Actions (MSCA)
Current limitations in cardiac tissue engineering revolve around the inability to fully recapitulate the structural organization and mechanical environment of native cardiac tissue. This study aims at developing organized ultrafine fiber scaffolds with improved biocompatibility and architecture in comparison to the traditional fiber scaffolds obtained by solution electrospinning. This is achieved by combining the additive manufacturing of a hydroxyl-functionalized polyester, (poly(hydroxymethylglycolide-co-epsilon-caprolactone) (pHMGCL), with melt electrospinning writing (MEW). The use of pHMGCL with MEW vastly improves the cellular response to the mechanical anisotropy. Cardiac progenitor cells (CPCs) are able to align more efficiently along the preferential direction of the melt electrospun pHMGCL fiber scaffolds in comparison to electrospun poly(epsilon-caprolactone)-based scaffolds. Overall, this study describes for the first time that highly ordered microfiber (4.0-7.0 mu m) scaffolds based on pHMGCL can be reproducibly generated with MEW and that these scaffolds can support and guide the growth of CPCs and thereby potentially enhance their therapeutic potential.
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