期刊
ADVANCED HEALTHCARE MATERIALS
卷 6, 期 18, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201700646
关键词
cancer therapy; nanomedicine; silica; theranostics; ultrasound biomedicine
资金
- National Key RAMP
- D Program of China [2016YFA0203700]
- National Natural Science Foundation of China [51672303, 30860270, 81401433]
- Natural Science Foundation of Hainan Province [30854, 813208]
- Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2013169]
- Development Fund for Shanghai Talents
Ultrasound (US)-based biomedicine has been extensively explored for its applications in both diagnostic imaging and disease therapy. The fast development of theranostic nanomedicine significantly promotes the development of US-based biomedicine. This progress report summarizes and discusses the recent developments of rational design and fabrication of silica-based micro/nanoparticles for versatile US-based biomedical applications. The synthetic strategies and surface-engineering approaches of silica-based micro/nanoparticles are initially discussed, followed by detailed introduction on their US-based theranostic applications. They have been extensively explored in contrast-enhanced US imaging, US-based multi-modality imaging, synergistic high-intensity focused US (HIFU) ablation, sonosensitizer-enhanced sonodynamic therapy (SDT), as well as US-triggered chemotherapy. Their biological effects and biosafety have been briefly discussed to guarantee further clinical translation. Based on the high biocompatibility, versatile composition/structure and high performance in US-based theranostic biomedicine, these silica-based theranostic agents are expected to pave a new way for achieving efficient US-based theranostics of disease by taking the specific advantages of material science, nanotechnology and US-based biomedicine.
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