期刊
ADVANCED HEALTHCARE MATERIALS
卷 6, 期 17, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201700500
关键词
antioxidants; neuropathic pain; porous polymersomes; superoxide dismutase
资金
- National Institutes of Health NCI [R01CA175480]
- Cervical Spine Research Society
- Catherine Sharpe Foundation
- PENN ITMAT-CT3N Pilot Project
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD-encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据