期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201700818
关键词
animal models; cell therapy; drug delivery; ischemia reperfusion; polyelectrolyte and hybrid capsules
资金
- Russian Science Foundation [17-73-10023, 17-15-01111]
- state project Science [11.7293.2017/8.9, 4.8192.2017/8.9, 4.5752.2017/8.9]
- Government of the Russian Federation [14.Z50.31.0004]
- NIH [R01 1R01NS096237]
- Tomsk Polytechnic University Competitiveness Enhancement Program [TPU-CEP-52/2017]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS096237] Funding Source: NIH RePORTER
Cell functionalization with recently developed various nano- and microcarriers for therapeutics has significantly expanded the application of cell therapy and targeted drug delivery for the effective treatment of a number of diseases. The aim of this progress report is to review the most recent advances in cell-based drug vehicles designed as biological transporter platforms for the targeted delivery of different drugs. For the design of cell-based drug vehicles, different pathways of cell functionalization, such as covalent and noncovalent surface modifications, internalization of carriers are considered in greater detail together with approaches for cell visualization in vivo. In addition, several animal models for the study of cell-assisted drug delivery are discussed. Finally, possible future developments and applications of cell-assisted drug vehicles toward targeted transport of drugs to a designated location with no or minimal immune response and toxicity are addressed in light of new pathways in the field of nanomedicine.
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