期刊
ADVANCED HEALTHCARE MATERIALS
卷 6, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201601377
关键词
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资金
- National Natural Science Foundation of China [81302175, 81502153, 81472345]
- Natural Science Foundation of Jiangsu Province [BK20150221]
- China Postdoctoral Science Foundation [2016M591926]
- Key Research & Development Plan of Jiangsu Province [BE2016646]
- Jiangsu Provincial Commission of Health and Family Planning [Q201608]
Gliomas are highly radioresistant tumors, mainly due to hypoxia in the core region of the gliomas and efficient DNA double-strand break repair. However, the design of a radiosensitizer incorporating the two above mechanisms is difficult and has rarely been reported. Thus, this study develops a hypoxic radiosensitizer-prodrug liposome (MLP) to deliver the DNA repair inhibitor Dbait (MLP/Dbait) to achieve the simultaneous entry of radiosensitizers with two different mechanisms into the glioma. MLP/Dbait effectively sensitizes glioma cells to X-ray radiotherapy (RT). Histological and microscopic examinations of dissected brain tissue confirm that MLP effectively delivers Dbait into the glioma. Furthermore, the combination of MLP/Dbait with RT significantly inhibits growth of the glioma, as assessed by in vivo bioluminescence imaging. These findings suggest that MLP is a promising candidate as a Dbait delivery system to enhance the effect of RT on glioma, owing to the synergistic effects of the two different radiosensitizers.
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