期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201700830
关键词
FRET; in vivo noninvasive imaging; prodrug nanoparticles
资金
- ERC [648528, 249835]
- LabEX NanoSaclay grant [ANR-10-LABX-0035]
- LabEx Chimie des Systemes Complexes
- CNRS
- French Ministry of Research
- European Research Council (ERC) [249835] Funding Source: European Research Council (ERC)
Forster resonance energy transfer (FRET) is used here for the first time to monitor the in vivo fate of nanoparticles made of the squalene-gemcitabine prodrug and two novel derivatives of squalene with the cyanine dyes 5.5 and 7.5, which behave as efficient FRET pair in the NIR region. Following intravenous administration, nanoparticles initially accumulate in the liver, then they show loss of their integrity within 2 h and clearance of the squalene bioconjugates is observed within 24 h. Such awareness is a key prerequisite before introduction into clinical settings.
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