期刊
BMB REPORTS
卷 50, 期 4, 页码 214-219出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2017.50.4.006
关键词
microRNAs; miR-200a-3p; Mitochondria dynamics; Mitochondria fragmentation; Mitochondrial fission factor
资金
- National Research Foundation of Korea (NRF) grant - Korea government [2014R1A2A1A11053431, 2012M3A9D1054517, 2012R1A5A2047939]
- National Research Foundation of Korea [2014R1A2A1A11053431, 2012R1A5A2047939, 2012M3A9D1054517] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据