4.7 Article

Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model

期刊

ADVANCED HEALTHCARE MATERIALS
卷 6, 期 5, 页码 -

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WILEY
DOI: 10.1002/adhm.201600549

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资金

  1. Texas Children's Hospital
  2. National Institutes of Health (R21)
  3. Cardiovascular Research Institute at Baylor College of Medicine
  4. Directorate For Engineering
  5. Div Of Chem, Bioeng, Env, & Transp Sys [1724640] Funding Source: National Science Foundation

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In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch. [GRAPHICS] .

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