期刊
CANCER SCIENCE
卷 108, 期 4, 页码 598-603出版社
WILEY
DOI: 10.1111/cas.13189
关键词
cytotoxic T-Lymphocytes; HLA-A11; HLA-A33; IgG; peptide vaccine
类别
资金
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [15H04831, 17K07229] Funding Source: KAKEN
The HLA-A11 or -A33 allele is found in approximately 18% or 10% of the Asian population, respectively, but each of which is a minor allele worldwide, and therefore no clinical trials were previously conducted. To develop a therapeutic peptide vaccine for each of them, we investigated immunological responses of advanced cancer patients with the HLA-A11(+)/A11(+) (n=18) or -A33(+)/A33(+) (n=13) allele to personalized peptide vaccine (PPV) regimens. The primary sites of HLA-A11+/A11+ or -A33+/A33+ patients were the colon (n=4 or 2), stomach (2 or 3), breast (3 or 2), lung and pancreas (2 or 2), and so on. For PPV, a maximum of four peptides were selected from nine different peptides capable of binding to HLA-A11 and -A33 molecules based on the pre-existing peptide-specific IgG responses. There were no severe adverse events related to PPV. At the end of the first cycle, peptide-specific CTL responses were augmented in 4/12 or 2/9 of HLA-A11(+)/A11(+) or -A33(+)/A33(+) patients, while peptide-specific IgG responses were augmented in 6/14 or 4/10 patients, respectively. Clinical responses consisted of four stable diseases and 14 progressive diseases in HLA-A11(+)/A11(+)patients, versus seven and six in -A33(+)/A33(+)patients, respectively. Further clinical study of PPV could be recommended because of the safety and positive immunological responses.
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