期刊
ACS SYNTHETIC BIOLOGY
卷 6, 期 11, 页码 2130-2135出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssynbio.7b00154
关键词
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资金
- Defense Advanced Research Projects Agency (DARPA) Living Foundries [HR0011-12-G-0067]
- Institute for Collaborative Biotechnologies from the U.S. Army Research Office [W91INF-09-0001]
- NSF [1522074]
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1522074] Funding Source: National Science Foundation
We present a formal language for specifying via constraints a design space of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spaces, and possesses algorithms for common operations on design spaces. The flexibility of this approach is demonstrated using a 16-gene nitrogen fixation pathway and genetic logic circuits.
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