期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 43, 期 3, 页码 297-308出版社
WILEY
DOI: 10.1111/ejn.13018
关键词
p21; p27; p53; peripheral nerve; PTEN; Rb1
资金
- Canadian Institutes of Health Research (CIHR) [FRN15686, 184584]
- Canadian Diabetes Association (CDA) [OG-3-12-3669]
- University of Alberta Hospital Foundation
- Department of Medicine and Division of Neurology, Faculty of Medicine and Dentistry, University of Alberta
- Alberta Innovates-Health Solutions (AI-HS)
Restoring critical neuronal architecture after peripheral nerve injury is challenging. Although immediate regenerative responses to peripheral axon injury involve the synthesis of regeneration-associated proteins in neurons and Schwann cells, an unfavorable balance between growth facilitatory and growth inhibitory signaling impairs the growth continuum of injured peripheral nerves. Molecules involved with the signaling network of tumor suppressors play crucial roles in shifting the balance between growth and restraint during axon regeneration. An understanding of the molecular framework of tumor suppressor molecules in injured neurons and its impact on stage-specific regeneration events may expose therapeutic intervention points. In this review we discuss how signaling networks of the specific tumor suppressors PTEN, Rb1, p53, p27 and p21 are altered in injured peripheral nerves and how this impacts peripheral nerve regeneration. Insights into the roles and importance of these pathways may open new avenues for improving the neurological deficits associated with nerve injury.
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