期刊
ACS MACRO LETTERS
卷 6, 期 2, 页码 150-154出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00015
关键词
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资金
- Austrian Science Fund (FWF) [P 27410-N28]
- European Union [EFRE RU2-EU-124/100-2010, M00146]
- Austrian Science Fund (FWF) [P27410] Funding Source: Austrian Science Fund (FWF)
Oxidation responsive polymers with triggered degradation pathways have been prepared via attachment of self-immolative moieties onto a hydrolytically unstable polyphosphazene backbone. After controlled main-chain growth, postpolymerization functionalization allows the preparation of hydrolytically stable poly(organo)phosphazenes decorated with a phenylboronic ester caging group. In oxidative environments, triggered cleavage of the caging group is followed by self-immolation, exposing the unstable glycine-substituted polyphosphazene which subsequently undergoes to backbone degradation to low-molecular weight molecules. As well as giving mechanistic insights, detailed GPC and H-1 and P-31 NMR analysis reveal the polymers to be stable in aqueous solutions, but show a selective, fast degradation upon exposure to hydrogen peroxide containing solutions. Since the post-polymerization functionalization route allows simple access to polymer backbones with a broad range of molecular weights, the approach of using the inorganic backbone as a platform significantly expands the toolbox of polymers capable of stimuli-responsive degradation.
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