Polymer-Protein Core-Shell Nanoparticies for Enhanced Antigen Immunogenicity

Nanoengineered vaccine platforms can be modeled after viruses and other pathogens with highly organized and repetitive structures that trigger the host immune system. Here we demonstrated a pyridine-grafted poly(e-caprolactone)-based polymer protein core shell nano particles (PPCS-NPs) platform can effectively trigger the host immune system and lead to significantly higher antibody titers.