期刊
ACS MACRO LETTERS
卷 6, 期 2, 页码 103-106出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00006
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资金
- Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT)
Novel multiblock polypeptides with a structure similar to the unique sequence observed in spider silk proteins (spidroins) were synthesized via a two-step chemical synthesis method, that is, chemoenzymatic polymerization, using papain followed by postpolycondensation. Two types of polypeptide fragments were prepared by chemoenzymatic polymerization: polyalanine as a hard block, which forms beta-sheets in the spider silk fibers, and poly(glycine-random-leucine) as a soft block. These two fragments were ligated by postpolycondensation using polyphosphoric acid as a condensing agent. Wide-angle X-ray diffraction (WAXD) and IR measurements revealed that the resulting multiblock polypeptides formed an antiparallel beta-sheet structure with a degree of crystallinity similar to that of spider silk, which resulted in a fibrous morphology. This work provides the first example of a synthetic multiblock polypeptide mimicking the secondary structures of spider silk.
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