期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 52, 期 3, 页码 304-313出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2017.1291577
关键词
Mitochondrial unfolded protein response; mitochondrial dysfunction; mitochondrial stress response; integrated stress response; mitochondria quality control
资金
- NIH [R01HL127891, R01AG047182]
Mitochondrial function is central to many different processes in the cell, from oxidative phosphorylation to the synthesis of iron-sulfur clusters. Therefore, mitochondrial dysfunction underlies a diverse array of diseases, from neurodegenerative diseases to cancer. Stress can be communicated to the cytosol and nucleus from the mitochondria through many different signals, and in response the cell can effect everything from transcriptional to post-transcriptional responses to protect the mitochondrial network. How these responses are coordinated have only recently begun to be understood. In this review, we explore how the cell maintains mitochondrial function, focusing on the mitochondrial unfolded protein response (UPRmt), a transcriptional response that can activate a wide array of programs to repair and restore mitochondrial function.
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