期刊
ACS MACRO LETTERS
卷 6, 期 10, 页码 1151-1155出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00649
关键词
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资金
- National Natural Science Foundation of China [21674022, 51703034]
- State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Energy dissipation underlies dynamic behaviors of the life system. This principle of biology is explicit, but its in vitro mimic is very challenging. Here we use an energy-dissipative self-assembly pathway to create a life-like polymer micellar system that can do periodic and self-adaptive pulsating motion fueled by cell energy currency, adenosine triphosphate (ATP). Such a micelle expansion-contraction behavior relies on transient supramolecular interactions between the micelle and ATP fuel. The micelles capturing ATPs will deviate away from the thermodynamic equilibrium state, driving a continuous micellar expansion that temporarily breaks the amphiphilic balance, until a competing ATP hydrolysis consumes energy to result in an opposing micellar contraction. As long as ATP energy is supplied to keep the system in out-of-equilibrium, this reciprocating process can be sustained, and the ATP level can orchestrate the rhythm and amplitude of nanoparticulate pulsation. The man-made assemblies provide a model for imitating biologically time-dependent self-assembly and periodic nanocarriers for programmed drug delivery.
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