期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 73, 期 -, 页码 229-245出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2017.03.025
关键词
Aquaculture; Crassostrea gigas; Larvae; Metabolism; Metabolomics; Ostreid herpesvirus
资金
- New Zealand Ministry of Business, Innovation and Employment [CAWX0802, CAWX1315]
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [CAWX0802] Funding Source: New Zealand Ministry of Business, Innovation & Employment (MBIE)
Early lifestages of the Pacific oyster (Crassostrea gigas) are highly susceptible to infection by OsHV-1 mu Var, but little information exists regarding metabolic or pathophysiological responses of larval hosts. Using a metabolomics approach, we identified a range of metabolic and immunological responses in oyster larvae exposed to OsHV-1 mu Var; some of which have not previously been reported in molluscs. Multivariate analyses of entire metabolite profiles were able to separate infected from non-infected larvae. Correlation analysis revealed the presence of major perturbations in the underlying biochemical networks and secondary pathway analysis of functionally-related metabolites identified a number of prospective pathways differentially regulated in virus-exposed larvae. These results provide new insights into the pathogenic mechanisms of OsHV-1 infection in oyster larvae, which may be applied to develop disease mitigation strategies and/or as new phenotypic information for selective breeding programmes aiming to enhance viral resistance. (C) 2017 Elsevier Ltd. All rights reserved.
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