期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 177, 期 4, 页码 557-561出版社
WILEY
DOI: 10.1111/bjh.14571
关键词
mantle cell lymphoma; NOXA; MCL1; Dinaciclib; FASNi
类别
资金
- Robert Bosch Foundation
Imbalances in the composition of BCL2 family proteins contribute to tumourigenesis and therapy resistance of mantle cell lymphoma (MCL), making these proteins attractive therapy targets. We studied the efficiency of dual targeting the NOXA/MCL1 axis by combining fatty acid synthase inhibitors (NOXA stabilization) with the CDK inhibitor Dinaciclib (MCL1 reduction). This combination synergistically induced apoptosis in cell lines and primary MCL cells and led to almost complete inhibition of tumour progression in a mouse model. Apoptosis was NOXA-dependent and correlated with the NOXA/MCL1 ratio, highlighting the importance of the NOXA/MCL1 balance for effective cell death induction in MCL.
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