期刊
BIOMOLECULES & THERAPEUTICS
卷 25, 期 3, 页码 231-238出版社
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2016.042
关键词
Myelin; Fragile X mental retardation protein; Translational control; Oligodendrocyte
资金
- NRF - Ministry of Education [NRF-2014R1A1A2059179]
- Korean Health Technology R&D Project, Ministry of health & welfare, Republic of Korea [HI12C0021]
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin by wrapping processes in a spiral pattern around neuronal axons through myelin-related gene regulation. Since these events occur at a distance from the cell body, post-transcriptional control of gene expression has strategic advantage to fine-tune the overall regulation of protein contents in situ. Therefore, many research interests have been focused to identify RNA binding proteins and their regulatory mechanism in myelinating compartments. Fragile X mental retardation protein (FMRP) is one such RNA binding protein, regulating its target expression by translational control. Although the majority of works on FMRP have been performed in neurons, it is also found in the developing or mature glial cells including oligodendrocytes, where its function is not well understood. Here, we will review evidences suggesting abnormal translational regulation of myelin proteins with accompanying white matter problem and neurological deficits in fragile X syndrome, which can have wider mechanistic and pathological implication in many other neurological and psychiatric disorders.
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