期刊
THERANOSTICS
卷 7, 期 12, 页码 3068-3077出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.18019
关键词
Intrinsic radiolabeling; Surface-enhanced resonance Raman scattering; SERS; Positron emission tomography; in vivo; Imaging
资金
- NIH [R01 EB017748, K08 CA16396]
- Pershing Square Sohn Prize by the Pershing Square Sohn Cancer Research Alliance
- Center for Molecular Imaging & Nanotechnology (CMINT)
- Center for Experimental Therapeutics (ETC)
- Molecularly Targeted Intra-Operative Imaging Grant
- MSKCC Office of Technology TDF Grant
- Damon Runyon Cancer Research Foundation [DRR-29-14]
- Commonwealth Foundation for Cancer Research
- National Science Foundation Integrative Graduate Education and Research Traineeship Grant [IGERT-0965983]
- MSKCC NIH Core Grant [P30 CA008748]
- NIH Shared Instrumentation Grant [1 S10 OD016207]
- Inveon PET/CT
A single contrast agent that offers whole-body non-invasive imaging along with the superior sensitivity and spatial resolution of surface-enhanced resonance Raman scattering (SERRS) imaging would allow both pre-operative mapping and intraoperative imaging and thus be highly desirable. We hypothesized that labeling our recently reported ultrabright SERRS nanoparticles with a suitable radiotracer would enable pre-operative identification of regions of interest with whole body imaging that can be rapidly corroborated with a Raman imaging device or handheld Raman scanner in order to provide high precision guidance during surgical procedures. Here we present a straightforward new method that produces radiolabeled SERRS nanoparticles for combined positron emission tomography (PET)-SERRS tumor imaging without requiring the attachment of molecular chelators. We demonstrate the utility of these PET-SERRS nanoparticles in several proof-of-concept studies including lymph node (LN) tracking, intraoperative guidance for LN resection, and cancer imaging after intravenous injection. We anticipate that the radiolabeling method presented herein can be applied generally to nanoparticle substrates of various materials by first coating them with a silica shell and then applying the chelator-free protocol.
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