期刊
THERANOSTICS
卷 7, 期 2, 页码 466-481出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.17411
关键词
Photothermal therapy; Bimodal Imaging; Prussian blue nanoparticles; Fe3O4 nanoparticles; Quantum Dots; Tumor targeting
资金
- National Key Research and Development Program of China [2016YFA0201400]
- State Key Program of National Natural Science of China [81230036]
- National Natural Science Foundation for Distinguished Young Scholars [81225011]
- National Natural Science Foundation of China [81371580]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]
A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS2-ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Both NIR fluorescence and MR imaging in vivo proved high accumulation of the nanoagent at tumor site due to its excellent CD44 receptor/magnetic dual targeting capability. After intravenous injection of the nanoagent and treatment of external magnetic field, the tumor in nude mice was efficiently ablated upon NIR laser irradiation and the tumor growth inhibition was more than 89.95%. Such nanotheranostic agent is of crucial importance for accurately identifying the size and location of the tumor before therapy, monitoring the photothermal treatment procedure in real-time during therapy, assessing the effectiveness after therapy.
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