期刊
THERANOSTICS
卷 7, 期 1, 页码 196-204出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.16899
关键词
Angiogenesis; super-resolution; ultrasound localization microscopy; microbubble contrast agent; acoustic angiography; biomarker
资金
- National Institutes of Health [R01CA170665, R01CA189479, R44CA165621, T32HL069768]
- NATIONAL CANCER INSTITUTE [P30CA016086, R01CA170665, R01CA189479, R44CA165621] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL069768] Funding Source: NIH RePORTER
Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet ultrasound has been limited in its ability to detect the microvascular changes associated with malignancy. Here, we demonstrate the potential of 'ultrasound localization microscopy' applied volumetrically in combination with quantitative analysis of microvascular morphology, as an approach to overcome this limitation. This pilot study demonstrates our ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe. Furthermore, it is observed that data from healthy and tumor-bearing tissue exhibit significant differences in microvascular pattern and density. Results suggests that with continued development of these novel technologies, ultrasound has the potential to detect biomarkers of cancer based on the microvascular ` fingerprint' of malignant angiogenesis rather than through imaging of blood flow dynamics or the tumor mass itself.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据