期刊
THERANOSTICS
卷 7, 期 3, 页码 764-774出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.15757
关键词
albumin nanoreactor; gadolinium oxide; photosensitizer; magnetic resonance imaging; photodynamic therapy
资金
- National Basic Research Program [2014CB931900]
- National Natural Science Foundation of China [31671016, 31422021, 51473109, 21505096]
- Postdoctoral Science Foundation of China [2015T80575, 2014M560442]
- Jiangsu Provincial Special Program of Clinical Medical Science [BL2014040]
- Suzhou Scientific and Technological Development Project [SYSD2013094]
- Priority academic program development of Jiangsu higher education institutions (PAPD)
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
- Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases [BM2013003]
Protein nanoparticles as nanocarriers are of particular interest in the field of cancer therapy. Nevertheless, so far a facile fabrication of theranostic protein nanoparticles have been explored with limited success for cancer imaging and therapy. In this work, we demonstrate the controllable synthesis of size-tunable Gd2O3@albumin conjugating photosensitizer (PS) (GA-NPs) using hollow albumin as the nanoreactor for magnetic resonance imaging (MRI)-guided photo-induced therapy. The growth of Gd2O3 nanocrystals within the hollow nanoreactors is well regulated through reaction time, and a typical PS (e.g. chlorin e6) is further conjugated with the protein corona of the nanoreactor through facile chemical coupling, followed by the formation of theranostic GA-NPs. GA-NPs exhibit good longitudinal relaxivity, ideal photostability, enhanced cellular uptakes, and preferable size-dependent tumor accumulation. Moreover, GA-NPs effectively generate remarkable photothermal effect, intracellular reactive oxygen species from Ce6, and subsequent cytoplasmic drug translocation, thereby leading to severe synergistic photothermal and photodynamic cell damages. Consequently, GA-NPs exhibit an in vivo size-dependent MRI capacity with enhanced imaging contrast for effective tumor localization, and also generate a potent synergistic photodynamic therapy/photothermal therapy efficacy under irradiation owing to their enhanced tumor accumulation and strong photo-induced cytotoxicity. These results suggest that GA-NPs can act as a promising theranostic protein nanoplatform for cancer imaging and photo-induced therapy.
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