期刊
THERANOSTICS
卷 7, 期 5, 页码 1192-1203出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.17881
关键词
stealthy nanocapsule; tumor suppression; phosphorylcholine; tumor microenvironment; benzoic-imine bond
资金
- National Natural Science Foundation of China [31270019]
- China Postdoctoral Science Foundation [2015M580109]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306036]
- Natural Science Foundation of Guangdong Province [2015A030313848]
- Guangdong Special Support Program
- Science and Technology Planning Project of Guangdong Province [2016A020217001]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20150529164918738, JCYJ20150430163009479, JCYJ20160301152300347]
The efficient delivery of anticancer drugs into tumor tissues to improve therapeutic efficacy remains an urgent demand. To satisfy this demand, a drug delivery system based on a stealthy nanocapsule was developed. This nanocapsule was fabricated by encapsulating stealthy cross-linked poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and benzaldehyde groups around the protein bovine serum albumin (BSA) followed by conjugation of doxorubicin (Dox) through a pH-responsive benzoic-imine bond. The in vitro results show that the Dox-conjugated nanocapsule (nBSA-Dox) released the drug under an acidic tumor microenvironment (pH similar to 6.5) and killed HepG2 human liver cancer cells. The half-life of Dox conjugated to nBSA in mice was significantly prolonged, and the area-under-curve of plasma Dox of the mice treated with nBSA-Dox was as much as 242 fold of free Dox. The in vivo results confirmed that this nanocapsule efficiently accumulated in tumor tissue and significantly suppressed the tumor growth.
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