期刊
THERANOSTICS
卷 7, 期 12, 页码 3007-3020出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.18460
关键词
degradable; silicon/carbon nanoparticles; photoacoustic imaging; chemo-thermal therapy
资金
- City University of Hong Kong [9610352]
- Research Grants Council of the Hong Kong [T23-713/11]
- National natural science foundation of China [51402343]
- Major State Basic Research Development Program of China (973 Program) [2013CB733802, 2014CB744503]
- Fundamental Research Funds for the Central Universities [20720160065, 20720150141]
- National Natural Science Foundation of China (NSFC) [81422023, 51273165, U1505221]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
The development of nanoscaled theranostic agents for cancer combination therapies has received intensive attention in recent years. In this report, a degradable hollow mesoporous PEG-Si/C-DOX NP is designed and fabricated for pH-responsive, photoacoustic imaging-guided highly effective chemo-thermal combination therapy. The intrinsic hollow mesoporous structure endows the as-synthesized nanoparticles (NPs) with a high drug loading capacity (31.1%). Under NIR (808 nm) irradiation, the photothermal conversion efficiency of the Si/C NPs is as high as 40.7%. Preferential accumulation of the PEG-Si/C-DOX NPs around tumor tissue was demonstrated with photoacoustic images. Cellular internalization of the NPs and release of the DOX in nuclei are shown with fluorescent images. With efficient NIR photothermal conversion and high DOX loading capacity, the PEG-Si/C-DOX NPs are demonstrated to have remarkable cancer-cell-killing ability and to achieve complete in vivo tumor elimination via combinational chemo-thermal therapy. Last but not least, the NPs show good biodegradability and biosafety, making them a promising candidate for multifunctional drug delivery and cancer theranostic.
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