期刊
THERANOSTICS
卷 7, 期 17, 页码 4168-4182出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.21274
关键词
Extracellular vesicles; exosomes; microvesicles; cardiovascular diseases; therapeutic agents; biomarkers
资金
- National Natural Science Foundation of China [81722008, 91639101, 81570362, 81400647]
- Innovation Program of Shanghai Municipal Education Commission [2017-01-07-00-09-E00042]
- Science and Technology Commission of Shanghai Municipality [17010500100]
- development fund for Shanghai talents
- National Institutes of Health (NCATS) [UH3 TR000901]
- Interdisciplinair Ontwikkelingsfonds-Kennisplatform (Centre of Excellence) [KP/12/009]
- VEGA SR [2/0061/16]
- American Heart Association [16GRNT30950010]
- National Institutes of Health (COBRE) [P20GM104936]
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs. In this review, we will first outline the current knowledge about the physical characteristics, biological contents, and isolation methods of EVs. We will then focus on the functional roles of cardiovascular EVs and their pathophysiological effects in CVDs, as well as summarize the potential of EVs as therapeutic agents and biomarkers for CVDs. Finally, we will discuss the specific application of EVs as a novel drug delivery system and the utility of EVs in the field of regenerative medicine.
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