期刊
THERANOSTICS
卷 7, 期 17, 页码 4183-4191出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.21299
关键词
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资金
- Canadian Institutes of Health Research [PJT-149083, PJT-153105]
- High-level Leading Talent Introduction Program of GDAS [2016GDASRC-0102]
Circular RNAs have been identified as naturally occurring RNAs that are highly represented in the eukaryotic transcriptome. Although a large number of circRNAs have been reported, circRNA functions remain largely unknown. CircRNAs can function as miRNA sponges, thereby reducing their ability to target mRNAs. We hypothesize that circRNAs may bind, store, sort, and sequester proteins to particular subcellular locations, and act as dynamic scaffolding molecules that modulate protein-protein interactions. Here, we review the biological implication and function of circRNA-protein interaction, and reveal a dynamic model of the interaction in various tissues, development stages and physiological conditions. Improved techniques to identify and characterize the dynamic RNA-protein interactions may elucidate the molecular mechanisms associated with the expression and functional diversity of circRNAs.
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