期刊
BRAIN STIMULATION
卷 10, 期 3, 页码 684-694出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2017.02.009
关键词
Cortical implant; Neuroprosthetic; Auditory cortex; Hearing
资金
- Deutsche Forschungsgemeinschaft (DFG), Cluster of Excellence Hearing4all [DFG EXC 1077]
Background: Intracortical microstimulation is one of the most common techniques to causally interfere with neuronal processing, but neuronal recordings spanning the whole cortical depth during stimulation are exceptionally rare. Objective/Hypothesis: Here we combined layer-specific intracortical microstimulation with extracellular recordings on the same shank of a linear multi-electrode array to study the effects of electrical stimulation in different cortical depths on intracortical processing in the auditory cortex in vivo. Methods: Population responses (local field potentials and multi-unit activity) were recorded from the auditory cortex of 8 guinea pigs under ketamine/xylazine anesthesia while single current pulses (charge-balanced, biphasic, square-wave, 0.1-45 mu A, 200 mu s/phase) were delivered in different cortical depths. Results: The cortical responses differed with a change in the stimulation parameters, with significant factors being the stimulating current (p < 0.0001), stimulation depth (p = 0.03) and the recording depth (p = 0.002) considering the local field potential amplitude. A cross-correlation analysis between responses evoked by intracortical microstimulation and physiological auditory stimuli revealed the closest match when stimulating the middle granular layer (p < 0.05). Conclusion: Intracortical response profiles to low-current intracortical microstimulation were layer specific. The most natural cortical response was achieved by stimulation in the thalamo-recipient layer. These findings contribute to a basis for designing cortical neuroprosthetics. (C) 2017 Elsevier Inc. All rights reserved.
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