期刊
STEM CELL RESEARCH & THERAPY
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13287-017-0585-3
关键词
Adipose-derived stem cells; Stem cell transplantation; Cardiovascular diseases; Differentiation; Paracrine effect
资金
- National Natural Science Foundation of China [81400199, 81600218]
- Natural Science Foundation of Jiangsu Province [BK20150321, BK20150320]
- Suzhou Municipal Science and Technology Foundation [SYS201414, SYS201540, SYS201675]
- Natural Science Foundation for Colleges and Universities in Jiangsu Province [15KJB180017]
Adipose-derived stem cells (ADSCs) are easily obtained and expanded, and have emerged as a novel source of adult stem cells for the treatment of cardiovascular diseases. These cells have been shown to have the capability of differentiating into cardiomyocytes, vascular smooth muscle cells, and endothelial cells. Furthermore, ADSCs secrete a series of paracrine factors to promote neovascularization, reduce apoptosis, and inhibit fibrosis, which contributes to cardiac regeneration. As a novel therapy in the regenerative field, ADSCs still face various limitations, such as low survival and engraftment. Thus, engineering and pharmacological studies have been conducted to solve these problems. Investigations have moved into phase I and II clinical trials examining the safety and efficacy of ADSCs in the setting of myocardial infarction. In this review, we discuss the differentiation and paracrine functions of ADSCs, the strategies promoting their therapeutic efficacy, and their clinical usage.
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