期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-02441-5
关键词
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资金
- National Natural Science Foundation of China (NSFC) [81502949]
- National Science and Technology Major Projects of China [2014ZX10005002-005]
- Natural Science Foundation of Guangdong Province [2015A030310482, 2016A030313149, 2016A010105015]
- Stratesgic Resources Service Network Program on Plant Genetic Resources Innovation of the Chinese Academy of Sciences [ZSZC-005]
- 'Twelfth Five-Year' National Science and Technology Support Project of China [2015BAD15B03]
- DongGuan Innovative Research Team Program [2014607101005]
A new acylphloroglucinol with a novel architecture including an unprecedented dearomatic dibenzofuran core, named callistemenonone A (1), was isolated from the leaves of Callistemon viminalis (Myrtaceae). The structure was fully characterized on the basis of extensive spectroscopic analysis, including UV, HRESIMS, as well as 1D and 2D NMR spectral data (HSQC, HMBC, and ROESY). The deduced structure represents the first example of a natural dibenzofuran with two phenyl moieties coupling through tertiary hydroxy and ketal carbons. A plausible biogenetic pathway involving oxidative coupling and dearomatization as key steps is proposed to account for the biosynthesis of this novel class of dibenzofuran. Moreover, antimicrobial assays, in conjunction with the time-killing and biophysical studies, revealed that 1 exerted potent bactericidal activity against a panel of methicillin resistant pathogenic microbes with a unique mechanism.
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