期刊
CURRENT PHARMACEUTICAL DESIGN
卷 23, 期 11, 页码 1639-1648出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612822666161021152932
关键词
Solid dispersion; controlled release; swellable polymers; dissolution rate; poorly water-soluble drugs; bioavailability; poor absorption
资金
- Australian Research Council's Discovery Early Career Researcher Award [DE160100900]
Poorly water-soluble drugs, which commonly face the issue of poor absorption and low bioavailability, have been under ongoing research of many formulation scientists for the past few decades. Solid dispersion is one of the most effective strategies in concerns for improving bioavailability of poorly water-soluble drugs. Either application of solid dispersions in dissolution enhancement of poorly water-soluble drugs or the use of swellable polymers in controlled drug release has been reported in pharmaceutical designs widely. However, a review of strategies of using swellable polymers in solid dispersion to take a full advantage of these polymers as a current perspective in facilitating drug bioavailability enhancement is still missing. In this review, we aim to provide a summary of techniques used to formulate a swellable polymer in solid dispersion especially a description of a suitable fabrication method in design of a controlled release solid dispersion.
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