期刊
IMMUNITY INFLAMMATION AND DISEASE
卷 5, 期 2, 页码 151-162出版社
WILEY
DOI: 10.1002/iid3.154
关键词
Diet; metabolic syndrome; mouse study; Vitamin D
类别
资金
- Human Capacity Development Program (Kurdistan Region Government)
- British Heart Foundation [PG/17/43/33041] Funding Source: researchfish
Introduction: Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D-3, to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity. Methods: We analyzed female LDLR-/- and LDLR+/+ mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation. Results: The groups on a high fat high sugar diet with supplementary Vitamin D-3, in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D-3, as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D-3. Beneficial changes were observed as early as five weeks' supplementation with Vitamin D-3 and extended to restoration of high fat high sugar diet induced decrease of bone mineral density. Conclusion: In summary, Vitamin D-3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR-/- and LDLR+/+ mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据