期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 154, 期 -, 页码 253-262出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.03.036
关键词
NIR light triggered; Controlled release; Thermosensitive hydrogel; Carbon nanotube; Imaging tracking
资金
- National Natural Science Foundation of China [81601595, 31200732]
- Natural Science Foundation of Tianjin, China [16JCYBJC27800, 14JCYBJC17400]
- Program for Innovative Research Team in Peking Union Medical College
Controlled drug release with on demand is an important challenge for drug delivery. Near-infrared (NIR) light triggered drug delivery reflected the development of a significant strategy to control drug release based on photothermal effects. Herein, a sustained and controlled drug delivery system was developed based on a PCL-PEG-PCL thermosensitive hydrogel combined with chitosan-multiwalled carbon nano tubes for a near infrared light triggered drug delivery. Carbon nanotubes that incorporate hydrogel can enhance the sustained effect of drug delivery by a dual-stage release and allow drug delivery by controlling light irradiation. This in situ photothermal process was monitored by thermal imaging and the controlled drug delivery of doxorubicin was tracked in real-time by fluorescence imaging in vivo based on the fluorescence ability of the drug using nude mice as models. The results suggest that the photothermal effect of the carbon nanotubes can disrupt the structure of the hydrogel with a gel-sol transition, triggering the release of the drug from the sustained drug delivery system by NIR irradiation while responding on demand. The sustained and controlled drug delivery has the potential to implement the accurate administration of hydrogel-based drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.
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