期刊
BIOMATERIALS
卷 128, 期 -, 页码 136-146出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.03.010
关键词
Positive feedback strategy; ROS-responsive; Mesoporous silica nanoparticle; Drug delivery; Tumor therapy
资金
- National Natural Science Foundation of China [51125014, 51233003]
- Ministry of Science and Technology of China [2016YFC1100703]
Here, a positive feedback strategy was utilized to amplify the concentration of intracellular reactive oxygen species (ROS) and a ROS-triggered self-accelerating drug release nanosystem (defined as T/ D@RSMSNs) was demonstrated for enhanced tumor chemotherapy. The mesoporous silica nanoparticles (MSNs) based nanocarriers were gated by beta-cyclodextrin (beta-CD) through the ROS-cleavable thioketal (TK) linker to encapsulate the anticancer drug doxorubicin hydrochloride (DOX) and ROS producing agent atocopheryl succinate (a-TOS), whose surface was further anchored with adamantane conjugated poly( ethylene glycol) chain (AD-PEG) via host-guest interaction. It was found that in human breast cancer (MCF-7) cells, T/D@RSMSNs could not only release DOX and alpha-TOS initiatively, but also lead to increased concentration of intracellular ROS, which could be used as new trigger to cut away TK linkage and then in turn facilitate the further release of DOX for enhanced chemotherapy. Both in vitro and in vivo experiments demonstrated that T/DCRSMSNs exhibited more significant antitumor activity in the human breast cancer than the traditional single-DOX loaded ROS-responsive nanocarrier. This novel ROStriggered self-accelerating drug release nanosystem with remarkably improved therapeutic effects could provide a general strategy to branch out the applications of existing ROS-responsive drug delivery systems (DDSs). (C) 2017 Elsevier Ltd. All rights reserved.
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