期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 93, 期 -, 页码 9-15出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.01.050
关键词
Bis(indolyl)methanes; Nitrosoalkenes; Indoles; Anti-cancer activity; Leukaemia; Lymphoma
资金
- Portuguese Agency for Scientific Research (Coimbra Chemistry Centre) [Pest-OE/QUI/UI0313/2014, BI-PEST-UI-4023-11]
- POPH/FSE
- FCT [SFRH/BPD/34569/2007]
- FEDER - European Regional Development Fund through the COMPETE Programme (Operational Programme for Competitiveness)
- National Funds through FCT [REEQ/481/QUI/2006, RECI/QEQQFI/0168/2012, CENTRO-07-CT62-FEDER-002012, RNRMN]
- Fundacao para a Ciencia e a Tecnologia (FCT)
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/34569/2007] Funding Source: FCT
A versatile and broad range approach to previously unknown bis(indolyl)methane oximes based on two consecutive hetero Diels Alder cycloaddition reactions of electrophilic conjugated nitrosoalkenes with indoles is disclosed. The cytotoxic properties and selectivity of some adducts against several human cancer cell lines pointing to a promising role in the development of anti-tumoural drugs, in particular for leukaemia and lymphoma. (C) 2015 Elsevier Masson SAS. All rights reserved.
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