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Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease
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BRAIN (2015)
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Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation
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JOURNAL OF NEUROSCIENCE (2015)
Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice
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Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease
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PLOS GENETICS (2015)
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation
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Neurotrophin receptor p75NTR mediates Huntington's disease-associated synaptic and memory dysfunction
Veronica Brito et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related Stages
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JOURNAL OF NEUROSCIENCE (2014)
Onset of Huntington's Disease: Can It Be Purely Cognitive?
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Cognitive deficits in animal models of basal ganglia disorders
Simon P. Brooks et al.
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PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model
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Disassociation of Histone Deacetylase-3 from Normal Huntingtin Underlies Mutant Huntingtin Neurotoxicity
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Induction of DARPP-32 by Brain-Derived Neurotrophic Factor in Striatal Neurons In Vitro Is Modified by Histone Deacetylase Inhibitors and Nab2
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MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice
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EXPERIMENTAL NEUROLOGY (2012)
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HUMAN MOLECULAR GENETICS (2012)
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Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
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NEUROBIOLOGY OF DISEASE (2012)
MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
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NUCLEIC ACIDS RESEARCH (2012)
Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease
Zhiyin Xun et al.
CELL REPORTS (2012)
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
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JOURNAL OF NEUROSCIENCE (2011)
HA novel approach to investigate tissue-specific trinucleotide repeat instability
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BMC SYSTEMS BIOLOGY (2010)
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset
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HUMAN MOLECULAR GENETICS (2009)
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NEUROBIOLOGY OF DISEASE (2009)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation
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JOURNAL OF NEUROSCIENCE (2007)
Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain
Peggy F. Shelbourne et al.
HUMAN MOLECULAR GENETICS (2007)
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
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MOLECULAR AND CELLULAR BIOLOGY (2007)
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PRION (2007)
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Alejandro Lloret et al.
HUMAN MOLECULAR GENETICS (2006)
Differential role for CBP and p300 CREB-binding domain in motor skill learning
Ana M. M. Oliveira et al.
BEHAVIORAL NEUROSCIENCE (2006)
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HUMAN GENETICS (2006)
Histone deacetylase 3 binds to and regulates the GCMa transcription factor
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NUCLEIC ACIDS RESEARCH (2006)
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JOURNAL OF NEUROSCIENCE (2005)
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NEUROSCIENCE (2004)
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Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
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HUMAN MOLECULAR GENETICS (2003)
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TRENDS IN GENETICS (2003)
Mismatch repair gene Msh2 modifies the timing of early disease in HdhQ111 striatum
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HUMAN MOLECULAR GENETICS (2003)
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NATURE GENETICS (2001)
Interference by Huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity
FC Nucifora et al.
SCIENCE (2001)
N-acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice
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NEUROREPORT (2000)
Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells
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HUMAN MOLECULAR GENETICS (2000)
Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?
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HUMAN MOLECULAR GENETICS (2000)
Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits
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BRAIN (2000)
Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
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CREB-binding protein sequestration by expanded polyglutamine
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HUMAN MOLECULAR GENETICS (2000)
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NEUROPSYCHOLOGIA (2000)
The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
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NEUROSCIENCE (2000)