期刊
BIOMACROMOLECULES
卷 18, 期 6, 页码 1825-1835出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.7b00267
关键词
-
资金
- Ministry of Trade, Industry Energy (MOTIE) [10062079, R0005303, R0005237]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) -Ministry of Education [NRF-2017R1A2B2002365]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10062079, R0005303] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2017R1A2B2002365, 31Z20130012935] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In cancer therapy, optimizing tumor-specific delivery, tumor distribution, and cellular uptake of a drug is important for ensuring minimal toxicity and maximum therapeutic efficacy. This study characterized the therapeutic efficacy of a stimulus responsive and dual targeting nanocarrier for a bioimaging-guided photothermal and chemotherapeutic platform. Hyaluronic acid (HA) conjugated with triphenylphosphonium (TPP) and boronic acid (BA) dial-linked beta-cyclodextrin (beta-CD) forms an inclusion complex with paclitaxel (PTX), creating a shell-like composite on a core of carbonized fluorescent polydopamine nanopartides (FNPs-pDA) applicable for photothermal therapy as well as bioimaging. The successful dial cross-linking between core@shells generates nanocarriers [FNPs-pDA@HA-TPP-CD-PTX], that can be used as,an extracellular HA- and intracellular TPP-mediated dual targeting system. The carbonized FNPs-pDA was cross-linked with the boronic acid groups of HA-TPP-CD-PTX to promote the formation of boronate esters for pH-mediated photothermal activity, which have shown time dependent complete PTX release along with a photothermal mediated response. The in vitro dual bioimaging and photothermal-chemotherapeutic activities were compared between cancer and normal cells. Lysosomal escape and, live/dead, cells staining confocal images highlight the promise of this system, which might open up a new approach, a simple and versatile method for site-specific synergetic drug delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据