期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep45457
关键词
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资金
- FCT-Foundation for Science and Technology [PTDC/DTP-PIC/0460/2012]
- FEDER through Eixo I do Programa Operacional Fatores de Competitividade (POFC) do QREN [COMPETE: FCOMP-01-0124-FEDER-028692]
- FEDER Funds through the Competitiveness and Internationalization Operational Program - COMPETE
- National Funds through FCT-Foundation for Science and Technology [POCI-01-0145-FEDER-PTDB/BBB-BQB/3804/2014]
- FCT of the Portuguese Ministry of Science and Higher Education [SFRH/BD/81458/2011]
- Institute for Biomedicine - iBiMED [UID/BIM/04501/2013]
- Ferticentro
- Fundação para a Ciência e a Tecnologia [PTDC/DTP-PIC/0460/2012, SFRH/BD/81458/2011] Funding Source: FCT
Many studies have reported a negative impact of lifestyle factors on testicular function, spermatozoa parameters and pituitary-gonadal axis. However, conclusions are difficult to draw, since studies in the general population are rare. In this study we intended to address the early and late short-term impact of acute lifestyle alterations on young men's reproductive function. Thirty-six healthy male students, who attended the Portuguese academic festivities, provided semen samples and answered questionnaires at three time-points. The consumption of alcohol and cigarette increased more than 8 and 2 times, respectively, during the academic festivities and resulted in deleterious effects on semen quality: one week after the festivities, a decrease on semen volume, spermatozoa motility and normal morphology was observed, in parallel with an increase on immotile spermatozoa, head and midpiece defects and spermatozoa oxidative stress. Additionally, three months after the academic festivities, besides the detrimental effect on volume, motility and morphology, a negative impact on spermatozoa concentration was observed, along with a decrease on epididymal, seminal vesicles and prostate function. This study contributed to understanding the pathophysiology underlying semen quality degradation induced by acute lifestyle alterations, suggesting that high alcohol and cigarette consumption are associated with decreased semen quality in healthy young men.
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