期刊
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
卷 1398, 期 1, 页码 108-119出版社
WILEY
DOI: 10.1111/nyas.13376
关键词
cucurbit[7]uril; host-guest complexes; supramolecular chemistry; excipients; formulation
资金
- Macau Science and Technology Development Fund [FDCT-020/2015/A1]
- Research Committee at the University of Macau [MYRG2016-00008-ICMS-QRCM, MYRG2016-00165-ICMS-QRCM]
Cucurbit[7] uril (CB[7]), belonging to the cucurbit[n] uril family (CB[n], n = 5-8, 10, or 13-15), may form hostguest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB[7] as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB[7] and the influence of CB[7] on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Through this systemic summary and analysis, we intend to stimulate further research efforts in this area and promote the use of CB[7] as an emerging pharmaceutical excipient to improve various properties of drug molecules (or active pharmaceutical ingredients).
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