相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
Matthew E. Kennedy et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice
Yanmei Lu et al.
BIOANALYSIS (2016)
Proteomic Substrate Identification for Membrane Proteases in the Brain
Stephan A. Mueller et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)
Molecular regulators of nerve conduction - Lessons from inherited neuropathies and rodent genetic models
Jun Li
EXPERIMENTAL NEUROLOGY (2015)
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
Tom Vanden Berghe et al.
IMMUNITY (2015)
The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans
Patrick C. May et al.
JOURNAL OF NEUROSCIENCE (2015)
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter beta-amyloid levels in the CNS
Biljana Georgievska et al.
JOURNAL OF NEUROCHEMISTRY (2015)
Retinal Toxicity Induced by a Novel -secretase Inhibitor in the Sprague-Dawley Rat
Mark R. Fielden et al.
TOXICOLOGIC PATHOLOGY (2015)
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
Robert Vassar et al.
JOURNAL OF NEUROCHEMISTRY (2014)
A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models
Dara Y. Kallop et al.
JOURNAL OF NEUROSCIENCE (2014)
Targeting the β secretase BACE1 for Alzheimer's disease therapy
Riqiang Yan et al.
LANCET NEUROLOGY (2014)
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease
Robert Vassar
ALZHEIMERS RESEARCH & THERAPY (2014)
β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease
Kelly Willemijn Menting et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Population Pharmacokinetic and Pharmacodynamic Analysis of Plasma Aβ40 and Aβ42 Following Single Oral Doses of the BACE1 Inhibitor AZD3839 to Healthy Volunteers
Angelica Quartino et al.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2014)
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
Cyril Cheret et al.
EMBO JOURNAL (2013)
Systematic Proteomic Analysis Identifies β-Site Amyloid Precursor Protein Cleaving Enzyme 2 and 1 (BACE2 and BACE1) Substrates in Pancreatic β-Cells
Ina Stuetzer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS
Claire E. Le Pichon et al.
PLOS ONE (2013)
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Paul J. Meakin et al.
BIOCHEMICAL JOURNAL (2012)
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2012)
ß-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment
Jun Cai et al.
EMBO MOLECULAR MEDICINE (2012)
β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects
Brian Hitt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Thorlakur Jonsson et al.
NATURE (2012)
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor
Patrick C. May et al.
JOURNAL OF NEUROSCIENCE (2011)
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W. Rajapaksha et al.
MOLECULAR NEURODEGENERATION (2011)
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases
Fuqiang Chen et al.
NATURE METHODS (2011)
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Eric Karran et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo
Jasvinder K. Atwal et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
The effects of pramipexole on prepulse inhibition and locomotor activity in C57BL/6J mice
Wei-li Chang et al.
BEHAVIOURAL PHARMACOLOGY (2010)
The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats
Martin Weber et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2010)
Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Matthew L. Hemming et al.
PLOS ONE (2009)
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
Daniel J. Cavanaugh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
A. V. Savonenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Realistic expectations of prepulse inhibition in translational models for schizophrenia research
Neal R. Swerdlow et al.
PSYCHOPHARMACOLOGY (2008)
Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons
Shannon D. Shields et al.
PAIN (2007)
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice
Kouhei Nishitomi et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Bace1 modulates myelination in the central and peripheral nervous system
Xiangyou Hu et al.
NATURE NEUROSCIENCE (2006)
Control of peripheral nerve myelination by the β-secretase BACE1
Michael Willem et al.
SCIENCE (2006)
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
D Dominguez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain:: implications for Alzheimer's disease therapeutics
SL Roberds et al.
HUMAN MOLECULAR GENETICS (2001)
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
Y Luo et al.
NATURE NEUROSCIENCE (2001)
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
HB Cai et al.
NATURE NEUROSCIENCE (2001)
Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon
NR Swerdlow et al.
BEHAVIOURAL PHARMACOLOGY (2000)
分享论文
