期刊
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
卷 2, 期 2, 页码 87-96出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2017.07.003
关键词
Systems metabolic engineering; Amino acid; Corynebacterium glutamicum; Escherichia coli
资金
- National High Technology Research and Development Program of China [2015AA021003]
- National Natural Science Foundation of China [31470211]
- Natural Science Foundation of Tianjin [17JCQNJC09500]
- Foundation of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education [2016IM104]
- Tianjin Key Lab of Industrial Microbiology (Tianjin University of Science Technology)
Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-focused approaches, systems biology-based approaches, evolutionary approaches and their applications in two major amino acid producing microorganisms: Corynebacterium glutamicum and Escherichia coli, are summarized. (c) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co.
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