期刊
CANCER AND METASTASIS REVIEWS
卷 36, 期 2, 页码 289-303出版社
SPRINGER
DOI: 10.1007/s10555-017-9675-z
关键词
Platelets; Aspirin; Cyclooxygenase-1; Cyclooxygenase-2; Chemoprevention; Acetylome
类别
资金
- Boone Pickens Distinguished Chair for Early Prevention of Cancer
- Duncan Family Institute
- Colorectal Cancer Moon Shot [P30CA016672-41, 1R01CA187238-01, 5R01CA172670-03, 1R01CA184843-01A1, 1R21CA181994]
- national Institute MD Anderson Education in Cancer Prevention [R25T CA557730]
After more than a century, aspirin remains one of the most commonly used drugs in western medicine. Although mainly used for its anti-thrombotic, anti-pyretic, and analgesic properties, a multitude of clinical studies have provided convincing evidence that regular, low-dose aspirin use dramatically lowers the risk of cancer. These observations coincide with recent studies showing a functional relationship between platelets and tumors, suggesting that aspirin's chemopreventive properties may result, in part, from direct modulation of platelet biology and biochemistry. Here, we present a review of the biochemistry and pharmacology of aspirin with particular emphasis on its cyclooxygenase-dependent and cyclooxygenase-independent effects in platelets. We also correlate the results of proteomic-based studies of aspirin acetylation in eukaryotic cells with recent developments in platelet proteomics to identify non-cyclooxygenase targets of aspirin-mediated acetylation in platelets that may play a role in its chemopreventive mechanism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据