4.7 Review

Sleep and Neurodegeneration A Critical Appraisal

期刊

CHEST
卷 151, 期 6, 页码 1375-1386

出版社

ELSEVIER
DOI: 10.1016/j.chest.2017.01.002

关键词

Alzheimer disease; dementia; Lewy Body dementia; multiple system atrophy; neurodegeneration; Parkinson disease; REM sleep behavior disorder; sleep

资金

  1. Alzheimer's Association
  2. Axovant
  3. GE Healthcare
  4. Navidea Biopharmaceuticals
  5. Piramal Healthcare
  6. Teva
  7. Alzheimer's Drug Discovery Foundation
  8. Genzyme/Sanofi
  9. Lundbeck
  10. Michael J. Fox Foundation
  11. National Institutes of Health

向作者/读者索取更多资源

Sleep abnormalities are clearly recognized as a distinct clinical symptom of concern in neurodegenerative disorders. Appropriate management of sleep-related symptoms has a positive impact on quality of life in patients with neurodegenerative disorders. This review provides an overview of mechanisms that are currently being considered that tie sleep with neurodegeneration. It appraises the literature regarding specific sleep changes seen in common neurodegenerative diseases, with a focus on Alzheimer disease and synucleinopathies (ie, Parkinson disease, dementia with Lewy bodies, multiple system atrophy), that have been better studied. Sleep changes may also serve as markers to identify patients in the preclinical stage of some neurodegenerative disorders. A hypothetical model is postulated founded on the conjecture that specific sleep abnormalities, when noted to increase in severity beyond that expected for age, could be a surrogate marker reflecting pathophysiological processes related to neurodegenerative disorders. This provides a clinical strategy for screening patients in the preclinical stages of neurodegenerative disorders to enable therapeutic trials to establish the efficacy of neuroprotective agents to prevent or delay the development of symptoms and functional decline. It is unclear if sleep disturbance directly impacts neurodegenerative processes or is a secondary outcome of neurodegeneration; this is an active area of research. The clinical importance of recognizing and managing sleep changes in neurodegenerative disorders is beyond doubt.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据