期刊
BIOFABRICATION
卷 9, 期 2, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1758-5090/aa6c3d
关键词
laser microstructuring; soft-lithography; biocompatible materials; endothelial cells; preclinical devices
资金
- UE, Ministerio de Economia y Competitividad [MAT2015-71119-R AEI/FEDER]
- Instituto de Salud Carlos III, Spain [ISCIII/PI14-01140/FEDER]
- Xunta de Galicia (Spain) - Secretaria Xeral de Universidades
- Fondo Social Europeo (FSE)
In this work a method for fabricating functionalized preclinical devices is presented. The manufacturing process combines a laser indirect writing technique to fabricate a soda-lime glass master and soft-lithography methods to obtain the final structure in polydimethylsiloxane (PDMS). The roughness of the device is modified in a controlled manner by applying a post-thermal treatment to the master, and thus devices with different roughness values are created. ThePDMSdevices are fully covered with human umbilical vein cells in a two-step process. In order to determine the most suitable device to perform bioassays, the cell attachment to the channel is evaluated with regards to the walls roughness when flow experiments are carried out.
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