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Sebastian Schafer et al.
NATURE GENETICS (2017)
Impact of titin strain on the cardiac slow force response
Younss Ait-Mou et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2017)
A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism
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CARDIOVASCULAR RESEARCH (2016)
Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres
Alexey V. Dvornikov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
L. Fusi et al.
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Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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STEM CELL REPORTS (2016)
Instrumentation to study myofibril mechanics from static to artificial simulations of cardiac cycle
Petr G. Vikhorev et al.
METHODSX (2016)
A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress
Ross Wilkinson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)
Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate
Maria Papadaki et al.
CARDIOVASCULAR RESEARCH (2015)
ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure
Byambajav Buyandelger et al.
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Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation
Mohit Kumar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
John T. Hinson et al.
SCIENCE (2015)
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Angharad M. Roberts et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure
Byambajav Buyandelger et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency
Steven Marston et al.
PLOS ONE (2015)
The Dilated Cardiomyopathy-Causing Mutation ACTC E361G in Cardiac Muscle Myofibrils Specifically Abolishes Modulation of Ca2+ Regulation by Phosphorylation of Troponin I
Petr G. Vikhorev et al.
BIOPHYSICAL JOURNAL (2014)
Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole
Mei Methawasin et al.
CIRCULATION (2014)
Gigantic Business Titin Properties and Function Through Thick and Thin
Wolfgang A. Linke et al.
CIRCULATION RESEARCH (2014)
Transmural heterogeneity of cellular level power output is reduced in human heart failure
Premi Haynes et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)
Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of cardiomyopathy
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FRONTIERS IN PHYSIOLOGY (2014)
The HCM-Associated Cardiac Troponin T Mutation K280N Increases the Energetic Cost of Tension Generation in Human Cardiac Myofibrils
Claudia Ferrara et al.
BIOPHYSICAL JOURNAL (2013)
Myofibrillar Ca2+ sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T
Christopher R. Bayliss et al.
CARDIOVASCULAR RESEARCH (2013)
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction
Nazha Hamdani et al.
CARDIOVASCULAR RESEARCH (2013)
Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca2 sensitivity
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CARDIOVASCULAR RESEARCH (2013)
Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations
Vasco Sequeira et al.
CIRCULATION RESEARCH (2013)
Dilated cardiomyopathy: the complexity of a diverse genetic architecture
Ray E. Hershberger et al.
NATURE REVIEWS CARDIOLOGY (2013)
Cardiomyocyte proliferation contributes to heart growth in young humans
Mariya Mollova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Truncations of Titin Causing Dilated Cardiomyopathy
Daniel S. Herman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils
John S. Walker et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)
Fibrosis in endstage human heart failure: Severe changes in collagen metabolism and MMP/TIMP profiles
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INTERNATIONAL JOURNAL OF CARDIOLOGY (2011)
A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy
Ralph Knoell et al.
CIRCULATION RESEARCH (2010)
Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy
Sebastian Carballo et al.
CIRCULATION RESEARCH (2009)
Functional Analysis of a Unique Troponin C Mutation, GLY159ASP, that Causes Familial Dilated Cardiomyopathy, Studied in Explanted Heart Muscle
Emma C. Dyer et al.
CIRCULATION-HEART FAILURE (2009)
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease
Michael Gramlich et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)
The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle
Andrew E. Messer et al.
PROTEOMICS CLINICAL APPLICATIONS (2009)
The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils
Alexandra Belus et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
Mutations in the cardiac Troponin C gene are a cause of idiopathic dilated cardiomyopathy in childhood
Juan Pablo Kaski et al.
CARDIOLOGY IN THE YOUNG (2007)
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation
Brandon J. Biesiadecki et al.
CIRCULATION RESEARCH (2007)
Tension generation and relaxation in single myofibrils from human atrial and ventricular myocardium
Nicoletta Piroddi et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Troponin phosphorylation and regulatory function in human heart muscle: Dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
Andrew E. Messer et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)
Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene
E Villard et al.
EUROPEAN HEART JOURNAL (2005)
Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy
SF Nagueh et al.
CIRCULATION (2004)
Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts
I Makarenko et al.
CIRCULATION RESEARCH (2004)
Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins
CM Warren et al.
ELECTROPHORESIS (2003)
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