期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 115, 期 -, 页码 115-154出版社
ELSEVIER
DOI: 10.1016/j.addr.2017.07.021
关键词
Nonviral vectors; Systemic gene delivery; Cancer gene therapy; Delivery cascade; Barriers of gene delivery; Nanomedicine; Stimuli-responsive; Long blood circulation; Tumor accumulation; Tumor penetration
资金
- National Basic Research Program [2014CB931900]
- National Natural Science Foundation of China (NSFC) [51390481, 51603181, U1501243]
- Fundamental Research Funds for the Central Universities [2016QNA4024]
Gene therapy represents a promising cancer treatment featuring high efficacy and limited side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic polymers and lipid-based nonviral gene vectors have many advantages and have been extensively explored for cancer gene delivery, but their low gene-expression efficiencies relative to viral vectors limit their clinical translations. Great efforts have thus been devoted to developing new carrier materials and fabricating functional vectors aimed at improving gene expression, but the overall efficiencies are still more or less at the same level. This review analyzes the cancer gene delivery cascade and the barriers, the needed nanoproperties and the current strategies for overcoming these barriers, and outlines PEGylation, surface-charge, size, and stability dilemmas in vector nanoproperties to efficiently accomplish the cancer gene-delivery cascade. Stability, surface, and size transitions (3S Transitions) are proposed to resolve those dilemmas and strategies to realize these transitions are comprehensively summarized. The review concludes with a discussion of the future research directions to design high-performance nonviral gene vectors. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据