期刊
CHINESE MEDICAL JOURNAL
卷 130, 期 10, 页码 1161-1168出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.4103/0366-6999.205847
关键词
Acute Respiratory Distress Syndrome; Extracorporeal Membrane Oxygenation; Mechanical Ventilation; Outcome
资金
- Tianjin Municipal Bureau of Health [12KG106]
Background: Little is known about the long-term outcomes of severe acute respiratory distress syndrome (ARDS) patients requiring extracorporeal membrane oxygenation (ECMO). This study aimed to investigate the 1-year outcomes of these patients or patients receiving mechanical ventilation (MV) and compare their health-related quality of life (HRQoL) to the general population. Methods: Severe ARDS survivors admitted to two ICUs in China between January 2012 and January 2014 were enrolled. Of the severe ARDS survivors enrolled, 1-year postdischarge, HRQoL assessment using the Short-Form 36 (SF-36) and EuroQol questionnaire dimensions, 6-min walking distance, chest computed tomography scan, pulmonary function, and arterial blood gas analysis were compared for ARDS patients with or without ECMO. Results: ARDS patients receiving ECMO had a significantly higher Acute Physiology and Chronic Health Evaluation II score (30.3 +/- 6.7 vs. 26.5 +/- 7.3, P = 0.036), lung injury score (3.3 +/- 0.4 vs. 2.8 +/- 0.5, P = 0.000), Sequential Organ Failure Assessment score (10.8 +/- 3.5 vs. 7.9 +/- 3.1, P = 0.000), lower PaO2 FiO2 ratio ([mmHg, 1 mmHg = 0.133 kPa], 68.3 +/- 16.1 vs. 84.8 +/- 16.5, P= 0.000), and increased extrapulmonary organ failure (2 [1, 3] vs. 1 [1, 1], P = 0.025) compared with patients not receiving ECMO. ECMO and non-ECMO survivors showed similar pulmonary function, morphological abnormalities, resting arterial blood gas values, and 6-min walking distance. Mild pulmonary dysfunction and abnormal morphology were observed in a few survivors. In addition, ECMO and non-ECMO survivors showed a similar quality of life. ECMO survivors showed lower SF-36 physical functioning and role-physical domain scores (minimum clinically significant difference at least 5 points), and non-ECMO survivors had similar outcome. Conclusions: One-year posthospital discharge, severe ARDS survivors receiving ECMO or MV demonstrated comparable outcomes. Compared with the general population, ARDS survivors showed reduced HRQoL. Pulmonary function and lung morphology revealed sufficient recovery with minor lung impairment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据