期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-06124-z
关键词
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资金
- Ministry of Science and Technology of China [2015CB964600, 2013CB967500]
- National Natural Science Foundation of China [31470038, 31470844]
- Fundamental Research Funds for the Central Universities
- Open Research Funds of the State Key Laboratory of Ophthalmology, Zhong Shan Ophthalmic Center, Sun Yat-sen University
- Foundation from Shanghai Municipal Health Bureau [20134y013]
- Foundation for the Young Talents by Tongji University [2013KJ054]
IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-beta interacts with IL-37, and potently enhances the binding affinity of IL-37 to the ALK1 receptor complex, thus allowing IL-37 to signal through ALK1 to activate pro-angiogenic responses. We further show that TGF-beta and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy. The result suggests that IL-37 induces pro-angiogenic responses through TGF-beta, which may act as the bridging molecule that mediates IL-37 binding to the TGF-beta receptor complex.
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